The proteasome assembly line

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Assembly line performance and modeling

Automobile sector forms the backbone of manufacturing sector. Vehicle assembly line is important section in automobile plant where repetitive tasks are performed one after another at different workstations. In this thesis, a methodology is proposed to reduce cycle time and time loss due to important factors like equipment failure, shortage of inventory, absenteeism, set-up, material handling, r...

متن کامل

Proteasome assembly: Biting the hand…

Proteasome assembly is regulated to ensure the enzyme is inactive until its active sites are compartmentalized within an interior aqueous chamber. In yeast, this depends on a dedicated chaperone that is trapped within the nascent proteasome, and degraded on maturation of the proteolytic subunits.

متن کامل

Chaperone-driven proteasome assembly.

Assembly of the 34-subunit, 2.5 MDa 26S proteasome is a carefully choreographed intricate process. It starts with formation of a seven-membered alpha-ring that serves as a template for assembly of the complementary beta-ring-forming 'half-proteasomes'. Dimerization results in a latent 20S core particle that can serve further as a platform for 19S regulatory particle attachment and formation of ...

متن کامل

Phosphatase UBLCP1 controls proteasome assembly

Ubiquitin-like domain-containing C-terminal domain phosphatase 1 (UBLCP1), an FCP/SCP phosphatase family member, was identified as the first proteasome phosphatase. UBLCP1 binds to proteasome subunit Rpn1 and dephosphorylates the proteasome in vitro However, it is still unclear which proteasome subunit(s) are the bona fide substrate(s) of UBLCP1 and the precise mechanism for proteasome regulati...

متن کامل

Catalytic mechanism and assembly of the proteasome.

3.3. Proteasome Inhibitors 1518 3.3.1. Peptide Aldehydes 1519 3.3.2. Boronic Acid Inhibitors 1519 3.3.3. -Lactones 1519 3.3.4. Epoxyketones 1519 3.3.5. Vinyl Sulfones 1519 3.3.6. Vinyl Ketones 1520 3.3.7. Cyclic Peptides 1520 3.3.8. Targeting of Cancer Cells 1520 4. Regulatory Particles Proteasome Activators 1520 4.1. 19S Regulatory Particle/PA70

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Nature

سال: 2009

ISSN: 0028-0836,1476-4687

DOI: 10.1038/459787a